کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4116824 1270280 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peripheral Hearing Loss Causes Hyperexcitability of the Inferior Colliculus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Peripheral Hearing Loss Causes Hyperexcitability of the Inferior Colliculus
چکیده انگلیسی

Growing evidence has been found to suggest that early development of the central auditory system is dependent on acoustic stimuli. Peripheral damage caused by noise exposure and ototoxic drugs can induce functional and anatomical changes along the auditory pathways. The inferior colliculus (IC) is a unique structure in the auditory system located between the primary auditory nuclei of the brainstem and the thalamus. Damage to the IC inhibitory circuitry may affect central auditory processing and sound perception. Here, we review some of the striking electrophysiological changes in the IC that occur after noise exposure and ototoxic drug treatment. A common occurrence that emerges in the IC after peripheral damage is hyperexcitability of sound-evoked response. The hyperexcitability of the IC is likely related with reduced inhibitory response that requires normal peripheral inputs. Early age hearing loss can result in a long lasting increased susceptibility to audiogenic seizure which is related to hyperactivity in the IC evoked by loud sounds. Our studies suggest that hearing loss can cause increased IC neuron responsiveness which may be related to tinnitus, hyperacusis, and audiogenic seizure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Otology - Volume 8, Issue 1, June 2013, Pages 39–43
نویسندگان
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