کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4119733 | 1270360 | 2010 | 10 صفحه PDF | دانلود رایگان |
SummaryThrombomodulin (TM) is down-regulated from the vascular endothelial surfaces and corresponds to disturbed dermal blood flow and microthrombus formation in the ischaemic skin flap. We examined the therapeutic potential of simvastatin which up-regulates endothelial cell TM expression and activity in the dorsal ischaemic skin flap model.The study was carried out on 30 rats, divided into three groups. Group 1 was treated with simvastatin at a dose of 5 mg kg−1 day−1 by intraperitoneal injection. Group 2 was treated with 1 mg kg−1 day−1 with a phosphate-buffered saline for 7 days. Group 3 was the control group. Tissue blood flow, vascularisation and the survival rate of the skin flaps from each group were compared. The mean surviving area of group 1 was higher than groups 2 and 3 (p < 0.05). The blood flow change rate did not decrease in the treatment group in contrast to the control groups at 3 cm and 5 cm (p < 0.05). Microangiography demonstrated decreased flap vascularity in groups 2 and 3. There was no evidence of necrosis or positive peroxidase staining for TM in group 1 at 3 cm and 5 cm., although it was negative in groups 2 and 3. In this study, it was demonstrated that simvastatin prevented shedding of endothelial TM and contributed to flap survival.
Journal: Journal of Plastic, Reconstructive & Aesthetic Surgery - Volume 63, Issue 10, October 2010, Pages 1723–1732