Labial minor salivary gland biopsy

Biopsy of the labial minor salivary glands (“lip biopsy”) is often used as part of the diagnostic workup for suspected Sjogren's syndrome, and is comparable in diagnostic accuracy to open parotid biopsy. While there are non-invasive tests that should be performed for Sjogren's workup, in challenging cases tissue diagnosis provides valuable information. When properly performed, this office procedure can be done with minimal discomfort for the patient. The indications, risks, and interpretation of lip biopsy are discussed along with a detailed description of a technique designed to ensure sufficient tissue for diagnosis.