کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4130931 1411123 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resetting the immune response after autologous hematopoietic stem cell transplantation for autoimmune diseases
ترجمه فارسی عنوان
تنظیم مجدد پاسخ ایمنی پس از پیوند سلول های بنیادی خونگرم اتولوگ با بیماری های خود ایمنی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

Autologous hematopoietic stem cell transplantation (AHSCT) is currently investigated as treatment for severe and refractory autoimmune diseases, such as multiple sclerosis (MS), systemic sclerosis (SSc), Crohn's disease (CD) and systemic lupus erythematosus. Randomized clinical trials in MS, SSc and CD have shown the efficacy of AHSCT to promote control of disease activity and progression, when compared to conventional treatment. The use of high dose immunosuppressive conditioning is essential to eliminate the autoimmune repertoire, and the re-infusion of autologous hematopoietic stem cells avoids long-term leucopenia by reconstitution of both immune and hematological systems. Recent studies showed that AHSCT is able to deplete the autoimmune compartment and further promote the formation of a new auto-tolerant immune repertoire, reducing the inflammatory milieu and leading to long-term clinical remission without any complementary post-graft treatment. Deep knowledge about the mechanisms of action related to AHSCT-induced remission is required for the management of possible post-AHSCT relapse and improvement of clinical protocols. This paper will review the mechanisms enrolled in the immune response resetting promoted by AHSCT in patients with autoimmune diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Research in Translational Medicine - Volume 64, Issue 2, April–June 2016, Pages 107–113
نویسندگان
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