کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4131104 1271188 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New issues in gastrointestinal stromal tumors of the stomach
ترجمه فارسی عنوان
مسائل جدید در تومورهای استرومائی گوارشی معده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

Gastrointestinal stromal tumors (GISTs) constitute the majority of mesenchymal tumors of the gastrointestinal tract. The activating mutations in the receptor tyrosine kinases KIT and PDFRA are key molecular changes in the pathogenesis of these tumors and their recognition has led to the development of targeted therapies. Approximately 10% of GISTs, referred to as wild-type, lack such mutations and respond poorly to treatment with tyrosine kinase inhibitors. These GISTs are almost exclusive to the stomach and include primarily tumors that occur in children and tumors that are part of several tumor syndromes. Recent studies have shown that most wild-type GISTs are succinate dehydrogenase deficient. This review summarizes current advances in the molecular biology of GISTs and discusses the clinical and pathologic features associated with different genotypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 20, Issue 6, June 2014, Pages 222–227
نویسندگان
, ,