کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4131143 | 1271193 | 2014 | 7 صفحه PDF | دانلود رایگان |
Human papillomavirus (HPV) is now well established as an important causative agent in a subset of head and neck cancers. HPV-related head and neck carcinomas are important to recognize because these malignancies are associated with better survival and an improved response to therapy when compared to their HPV-negative counterparts. HPV-related head and neck cancer characteristically takes the form of a non-keratinizing squamous cell carcinoma. Widespread HPV testing of head and neck tumours, however, has revealed variants that depart from the standard HPV-related squamous cell carcinoma morphology. Most recently, examples of HPV-related carcinomas that actually lack a squamous phenotype, at least partially, have been reported. This manuscript will discuss these non-squamous variants of HPV-related head and neck carcinomas: adenosquamous carcinoma, adenocarcinoma, small cell carcinoma, sarcomatoid carcinoma, and sinonasal carcinoma with adenoid cystic-like features.
Journal: Diagnostic Histopathology - Volume 20, Issue 8, August 2014, Pages 301–307