کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4131188 1271199 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IgG4-related lymphadenopathy and IgG4-related lymphoma: moving targets
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
IgG4-related lymphadenopathy and IgG4-related lymphoma: moving targets
چکیده انگلیسی

IgG4 is the least common of all the IgG subclasses. In recent years an uncommon systemic disease characterized by variable manifestations that may include the presence of tumour-like sclerosing lesions in a variety of extranodal sites, lymphadenopathy, presence of increased numbers of IgG4+ plasma cells in affected tissues, elevated serum IgG4 level, frequent presence of autoantibodies and often, a good response to steroid therapy or Rituximab has been described. The disorder has been called IgG4-related sclerosing disease, IgG4-related systemic disease and IgG4-related autoimmune disease; currently the preferred designation is IgG4-related disease (IgG4-RD). In addition to other changes that may be found in association with IgG4-RD, some investigators have suggested that IgG4-RD may serve as a substrate for the development of lymphoma.This review focuses on lymphadenopathy associated with IgG4-RD and also explores the significance of isolated lymphadenopathy with increased numbers of IgG4+ plasma cells. Emerging data on lymphomas arising in association with IgG4-RD and the possibility of an increased risk of lymphoma in patients with IgG4-RD are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 19, Issue 4, April 2013, Pages 128–139
نویسندگان
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