Paediatric histiocytic tumors

The histiocytoses are a diverse collection of uncommon diseases that include accumulations and proliferations of macrophages and dendritic cells. In this review we survey the majority of histiocytic proliferations that affect children. We emphasize the practical diagnostic features, differential diagnosis, and consider new information on Langerhans cell histiocytosis and related lesions. We describe the various non-Langerhans cell histiocytoses, especially the juvenile xanthogranuloma family of lesions including reticulohistiocytoma, Rosai-Dorfman disease, and overlap, combined and sequential histiocytic lesions.