کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4131373 1271224 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of basal-like breast cancer: an update
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Characterization of basal-like breast cancer: an update
چکیده انگلیسی

Basal-like breast cancers express genes and proteins associated with the basal layer of mammary epithelium and account for 10–25% of breast cancers. These tumours are of particular interest because they follow an aggressive clinical course and currently lack any form of standard targeted systemic therapy. Over recent years, numerous studies have sought to further characterize this sub-group and dissect out the molecular features that define them. Several biomarkers represent credible novel therapeutic targets and can be evaluated using routine laboratory techniques. As such the basal-like sub-type is becoming increasingly relevant to the histopathologist. However, since recognition of this sub-type is not part of the minimum dataset for breast cancer reporting, many will be unfamiliar with diagnosing these lesions. In this paper, we review the key characteristics of basal-like cancers, discuss closely related entities (triple negative and hereditary breast cancer), and consider the role of molecular markers implicated in these tumours.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 18, Issue 3, March 2012, Pages 104–111
نویسندگان
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