کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4131660 1271254 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anal spindle cell lesion
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Anal spindle cell lesion
چکیده انگلیسی

Anal lumps are often clinically diagnosed as thrombosed or torted haemorrhoids or polyps. We report the case of an elderly woman who presented with a polypoid anal lesion, which showed pleomorphic spindle cell morphology on microscopy. Immunohistochemical stains revealed this to be a melanoma, which diffusely and strongly expressed CD117/c-kit protein. There is potential for misdiagnosis of CD117-positive amelanotic anal melanoma as a gastrointestinal stromal tumour (GIST), if a panel of immunohistochemistry markers is not performed. Melanoma comprises 0.25–1.25% of all anorectal malignancies. They are highly aggressive tumours, being unresponsive to both radical and local control with a poor 5-year survival of 10–15%. Previous studies have reported CD117 positivity in a small number of anorectal melanomas, a minority of which have shown c-kit mutation similar to those in GISTs. Melanomas are resistant to conventional chemotherapy and radiation and the presence of a c-kit mutation may offer a possible new alternative via gene-targeted therapy using the c-kit inhibitor imatinib Glivec. Accordingly we reviewed the literature and submitted the tumour for KIT mutational analysis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 15, Issue 1, January 2009, Pages 51–54
نویسندگان
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