کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4137198 | 1272013 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transition of pathophysiological significance of plasminogen activator inhibitor—From a chief player in antiinflammation, antifibrinolysis to that in the development of insulin resistance
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transition of pathophysiological significance of plasminogen activator inhibitor—From a chief player in antiinflammation, antifibrinolysis to that in the development of insulin resistance Transition of pathophysiological significance of plasminogen activator inhibitor—From a chief player in antiinflammation, antifibrinolysis to that in the development of insulin resistance](/preview/png/4137198.png)
چکیده انگلیسی
In the early phase of research, plasminogen activator inhibitor (PAI) was regarded as a negative regulator of fibrinolytic system, but the later study clarified that the changes in PAI level is closely related to risk factors of various pathologic processes of the lifestyle-related diseases. It is accepted that PAI-1 is a risk factor of the cardiovascular event in lifestyle-related diseases by recent researches analyzing the detailed function of PAI-1. In this review paper, we described the transition of pathophysiological significance of PAI based on many research papers especially from ours, which clarified the mechanism on protein expression of PAI, especially PAI-1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathophysiology - Volume 17, Issue 2, April 2010, Pages 109–118
Journal: Pathophysiology - Volume 17, Issue 2, April 2010, Pages 109–118
نویسندگان
Tadayoshi Kosugi, Mariko Nakamura, Masanori Sunagawa,