Tumor trofoblástico del lecho placentario. Presentación de un caso y revisión de la literatura

Placental site trophoblastic tumour is rare, being one of the gestational trophoblastic neoplasms that comprises a group of tumours with potential for local invasion and metastases. We report a case of placental site trophoblastic tumour in a 33 year-old woman. Macroscopically the uterine wall showed a 3.5 × 2.5 cm haemorrhagic soft tumour that occupied almost the entire wall with a perforation point in the fundus. Histologically there was diffuse infiltration of large, polyhedral cells with large, irregular nuclei and occasionally bi- and multinucleated cells. They occurred either individually or in sheets dissecting muscle fibres. Immunohistochemistry revealed CK AE1/AE3, placental lactogen and inhibine but not hCG and p63 expression. Adverse prognostic factors are discussed and the relevant literature is reviewed.