کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4138261 1272135 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome
ترجمه فارسی عنوان
نقش آزمایشگاه بالینی پاتولوژی در ارزیابی کارسینوم آندومتر برای سندرم لینچ
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

Molecular diagnostic testing of endometrial carcinomas in the pathology laboratory has recently emerged as a key component of the clinical evaluation of Lynch syndrome in many centers. Testing modalities involve immunohistochemical and PCR-based analyses. This article outlines the routine application of these analyses, provides a practical guide for troubleshooting some of the common technical issues related to their performance, and reviews common pitfalls in their interpretation. Discrepancies between tissue testing and genetic testing results are discussed in the context of the current understanding of endometrial cancer biology. The merits of universal versus targeted tissue testing based on clinical patient history and histological tumor appearance are also addressed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Diagnostic Pathology - Volume 31, Issue 3, May 2014, Pages 195–204
نویسندگان
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