Pathology of lung transplantation

The International Society for Heart and Lung Transplantation has a standardized nomenclature for the evaluation of lung allografts. Rejection of the lung allograft is divided into acute and chronic forms. Acute cellular rejection is characterized by perivascular accumulations of mononuclear cells and eosinophils; bronchiolar inflammation is also included in the grading scheme. Acute antibody-mediated rejection in lung allografts is not well defined. Chronic rejection is manifest by fibrous scarring narrowing the lumen of bronchioles, arteries, and veins. The diagnosis of rejection requires the exclusion of infection and other pathology in the allograft.