DNA copy number variants: A potentially useful predictor of early onset renal failure in boys with posterior urethral valves

The CNVs >100 Kb were significantly associated with early onset renal failure in children with PUV. Prenatal detection of CNV could help to identify foetuses at high risk of severe renal impairment in cases of suspected PUV, especially in cases without oligohydramnios or severe pulmonary hypoplasia. These preliminary results should be confirmed in a larger cohort of patients.121Summary Figure. Box plot graphic representation of nadir of creatinine value during the first year of life according to the presence of CNV (CNV+) or the absence of CNV (CNV−).