Immediate 1-month efficacy of desmopressin and anticholinergic combination therapy versus desmopressin monotherapy in the treatment of pediatric enuresis: A meta-analysis

This study was able to summarize the immediate 1-month efficacy of combination therapy compared with desmopressin monotherapy in the treatment of pediatric enuresis. For both treatment-naive and desmopressin-resistant pediatric enuresis, combination therapy of desmopressin with an anticholinergic agent is well tolerated and resulted in a significantly better immediate 1-month response rate than desmopressin monotherapy.Table. Summary table of meta-analysis pooled effect estimate (Risk Ratio) on combination therapy versus Monotherapy.Immediate 1-month response rate comparisonCombination therapyMonotherapyRisk ratio95% CI>90% response rateTotal subject>90% response rateTotal subjectTreatment naive49101281021.74(1.20-2.52)Treatment resistant16794753.77(1.32-10.77)Overall total treatment effect65180321771.89(1.34-2.68)Note heterogeneity and sensitivity tests: tau square = 0, chi square = 2.52; p = 0.47; I2 = 0%.Total overall effect: Z = 3.59 (p = 0.0003).