The variations in the AXIN1 gene and susceptibility to cryptorchidism

We assessed the impact of the genetic variability of the AXIN1 gene on cryptorchidism. We have offered primary evidence that the T allele and T/T genotype of rs370681 polymorphisms and C/T genotype of rs1805105 polymorphisms in AXIN1 gene are more frequent in patients with cryptorchidism.Table. Three tag SNPs in AXIN1 gene and cryptorchidism risk.Tag SNPGenetic modelDominantRecessiveOverdominantOR (95% CI)pOR (95% CI)P-valueOR (95% CI)prs3706812.44 (1.47-4.00)4e−042.56 (1.22-5.26)0.0121.54 (0.96-2.50)0.074rs18051051.64 (1.02-2.63)0.0411.01 (0.44-2.31)0.981.72 (1.05-2.86)0.032rs129218621.44 (0.67-3.06)0.343.22 (0.37-27.91)0.231.22 (0.55-2.74)0.62Note. Values in bold indicate a significant difference at the 5% level. OR = odds ration; SNP = single nucleotide polymorphism.