کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4162564 1274284 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of federal warnings on publically funded desmopressin utilization among children in Ontario
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
The impact of federal warnings on publically funded desmopressin utilization among children in Ontario
چکیده انگلیسی

ObjectiveTo determine whether safety warnings issued by health regulatory agencies regarding desmopressin treatment influenced treatment rates among children.Patient population and methodsWe conducted a time-series analysis using health administrative data from Ontario, Canada, between January 1, 2003 and March 31, 2010. We examined desmopressin prescribing rates among children (<13 years) and investigated the impact of a United States Food and Drug Administration warning (December 2007) and a subsequent Health Canada warning (July 2008) on these rates. A secondary analysis stratified rates according to route of administration.ResultsOn average, quarterly desmopressin treatment rates were 29.8% lower following the two warnings (4.7 per 1000 population) compared with the period prior to warnings being issued (6.7 per 1000 population). Structural break analyses identified a significant decrease in overall desmopressin prescribing rates in Q3 2008, with the 95% confidence interval (CI) spanning both safety warnings (Q4 2007 to Q1 2009). A secondary analysis of prescribing rates for oral formulations found consistent results (structural break Q4 2008, 95% CI Q2 2007 to Q2 2009). The average quarterly prescribing rate of intranasal formulations declined by 73.1% following the warnings compared with the period preceding the warnings.ConclusionSafety warnings issued by regulatory agencies dramatically influenced desmopressin use among Ontario’s children.


► Desmopressin use can lead to serious adverse events, including hyponatremia.
► This study investigates the impact of safety warnings on desmopressin use.
► Safety warnings led to a reduction in desmopressin prescribing in children.
► Warnings from regulatory agencies can influence physician prescribing behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Urology - Volume 8, Issue 3, June 2012, Pages 249–253
نویسندگان
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