The destructive combination of Scediosporium apiosperum lung disease and exuberant inflammation in cystic fibrosis

SummaryThis paper describes a patient whose decline over two years was precipitous, from an active independent life with lung function (FEV1) above 50% to requiring transplantation. The main pathogen on sputum culture throughout that period was Scediosporium apiosperum. The epidemiology pathogenicity and treatment of this fungal pathogen are discussed.