کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4171545 1275659 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Innate immune activation and cystic fibrosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Innate immune activation and cystic fibrosis
چکیده انگلیسی

SummarySince inflammation and infection occur so early in infancy in cystic fibrosis, the function of innate immune defence in cystic fibrosis has been questioned by many investigators. This review aims to summarize the findings relating to the physical, humoral and cellular components of innate immune defence in cystic fibrosis, and highlights the roles of neutrophils, macrophages and epithelial cells in these activities. In addition, recently identified links between antioxidant defences and cystic fibrosis transmembrane conductance regulator (CFTR) function, and how these may impact on innate lung defence, are summarized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Paediatric Respiratory Reviews - Volume 9, Issue 4, December 2008, Pages 271–280
نویسندگان
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