Neuroblastoma

Neuroblastoma is the most common extra cranial solid tumour in childhood. It is a fascinating and enigmatic tumour showing behaviour ranging from biological resistance to multimodal cancer therapies to complete spontaneous regression. The majority of children presenting with neuroblastoma have ‘high risk disease’ with distant metastases at primary diagnosis associated with considerable (more than50%) mortality. New targeted therapies are crucial to improve survival. These are being pursued through advances in the basic sciences alongside energetic translational clinical research efforts.