کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4186538 1608191 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does psychomotor retardation define a clinically relevant phenotype of unipolar depression?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Does psychomotor retardation define a clinically relevant phenotype of unipolar depression?
چکیده انگلیسی

BackgroundThe recognition and assessment of psychomotor retardation may have implications for better definition of the clinical phenotypes of depression. The aim of this study was to assess the clinical correlates of psychomotor retardation endorsed at any time during the patients' lifetime (LPR).MethodsThe study sample included 291 patients with non-psychotic major depressive disorder (MDD) participating in the clinical trial, “Depression: The Search for Treatment-Relevant Phenotypes.” Psychomotor retardation was measured using a factor derived from the Mood Spectrum Self-Report (MOODS-SR) assessment.Using a pre-defined cut-off score on the lifetime psychomotor retardation (LPR) factor of the MOODS-SR, participants were classified into high and low scorers. Logistic regression analysis was used to evaluate the relationship between LPR and subthreshold bipolarity.ResultsCompared to low scorers, participants with high scores on the LPR factor had greater severity of depression and more bipolarity indicators.ConclusionsThe MOODS-SR appears to be helpful to identify clinical phenotypes of unipolar depression and to highlight the usefulness of a lifetime approach to the assessment of psychopathology in the characterisation of patients with unipolar depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 129, Issues 1–3, March 2011, Pages 296–300
نویسندگان
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