کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4199901 1279345 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to Hydroxyurea and Pregnancy Outcomes in Patients With Sickle Cell Anemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Exposure to Hydroxyurea and Pregnancy Outcomes in Patients With Sickle Cell Anemia
چکیده انگلیسی
The Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) was a randomized double-blind placebo-controlled trial to test whether hydroxyurea could reduce the rate of painful crises in adults who had at least 3 painful crises per year. Because hydroxyurea is known to be carcinogenic, mutagenic, and teratogenic in animals, a major inclusion criterion in MSH was the use of contraceptives both by females and males in order to avoid exposure of the fetus to hydroxyurea. Despite this precautionary measure, some women became pregnant while taking hydroxyurea or their male partners were on hydroxyurea. We followed surviving patients who were enrolled in the original MSH trial for up to 17 years postrandomization. Our findings suggest that exposure of the fetus to hydroxyurea does not cause teratogenic changes in those pregnancies that terminate in live birth whether full term or premature. This seems to be true whether the parent taking hydroxyurea was the mother or the father. The same argument seems to apply for exposure to opioids. However, it will take a much longer follow-up of many more hydroxyurea-exposed sickle cell disease subjects to establish the results conclusively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the National Medical Association - Volume 101, Issue 10, October 2009, Pages 1046-1051
نویسندگان
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