کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4207952 1280423 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Skeletal muscle contractility and fatigability in adults with cystic fibrosis
ترجمه فارسی عنوان
انقباض عضلانی اسکلتی و خستگی در بزرگسالان مبتلا به فیبروز کیستیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی

BackgroundRecent discovery of cystic fibrosis transmembrane conductance regulator expression in human skeletal muscle suggests that CF patients may have intrinsic skeletal muscle abnormalities potentially leading to functional impairments. The aim of the present study was to determine whether CF patients with mild to moderate lung disease have altered skeletal muscle contractility and greater muscle fatigability compared to healthy controls.MethodsThirty adults (15 CF and 15 controls) performed a quadriceps neuromuscular evaluation using single and paired femoral nerve magnetic stimulations. Electromyographic and mechanical parameters during voluntary and magnetically-evoked contractions were recorded at rest, during and after a fatiguing isometric task. Quadriceps cross-sectional area was determined by magnetic resonance imaging.ResultsSome indexes of muscle contractility tended to be reduced at rest in CF compared to controls (e.g., mechanical response to doublets stimulation at 100 Hz: 74 ± 30 Nm vs 97 ± 28 Nm, P = 0.06) but all tendencies disappeared when expressed relative to quadriceps cross-sectional area (P > 0.5 for all parameters). CF and controls had similar alterations in muscle contractility with fatigue, similar endurance and post exercise recovery.ConclusionsWe found similar skeletal muscle endurance and fatigability in CF adults and controls and only trends for reduced muscle strength in CF which disappeared when normalized to muscle cross-sectional area. These results indicate small quantitative (reduced muscle mass) rather than qualitative (intrinsic skeletal muscle abnormalities) muscle alterations in CF with mild to moderate lung disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 15, Issue 1, January 2016, Pages e1–e8
نویسندگان
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