کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4208067 1280426 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is infection with hypermutable Pseudomonas aeruginosa clinically significant?
ترجمه فارسی عنوان
آیا عفونت با سودوموناس آئروژینوزا به طور بالقوه قابل توجه است؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی

BackgroundHypermutable Pseudomonas aeruginosa (HPA) with high mutation rate due to defects in the DNA mismatch repair genes are frequently isolated in the sputum of cystic fibrosis (CF) patients. These isolates tend to be multidrug resistant and may be better adapted to the CF lung environment. However, the clinical significance of this infection has not been determined.MethodsThis prospective study enrolled patients with PA infection attending CF clinics in Jerusalem between 2010 and 2011. Mutation frequency of pseudomonas isolates was determined by quantification of colonies resistant to rifampicin.ResultsOf the 73 patients enrolled, 22 (30%) were infected with HPA. Average mutation frequency was 2.95 × 10− 4 in HPA and 1 × 10− 7 in non-HPA.Pulmonary function tests, number of pulmonary exacerbations and the response to antibiotic therapy were similar between patients infected with HPA and non-HPA isolates. The only predictors for infection with HPA were resistance to multiple antimicrobial categories (OR = 4.8, 95% CI: 1.8–12.4) and previous use of inhaled colistin (OR = 8.1, 95% CI: 2–30). Resistant mutant subpopulation analysis was a poor screening test for identifying HPA isolates.ConclusionsInfection with hypermutable strains represents the marked ability of PA to adapt to the lung environment, but was not associated with worse clinical outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 14, Issue 3, May 2015, Pages 347–352
نویسندگان
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