کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4209150 1280473 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cystic fibrosis gene mutations and gastrointestinal diseases
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Cystic fibrosis gene mutations and gastrointestinal diseases
چکیده انگلیسی

BackgroundThis study examined if CF mutation heterozygosity is associated with diseases of gastrointestinal epithelial barrier function.Design and methodsSwedish registers identified 865 patients with a diagnosis of CF between 1968 and 2003 and matched with 8101 individuals without CF. Gastrointestinal disease risk was examined among 1534 biological parents and 1396 siblings of CF patients, compared with 15,526 parents and 15,542 siblings of individuals without CF.ResultsFirst-degree relatives of CF patients were not at lower risk of the gastrointestinal diseases, in contrast with a raised risk among CF patients.ConclusionHeterozygosity for CF gene mutations does not protect against gastrointestinal diseases where impaired barrier function may be relevant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 9, Issue 4, July 2010, Pages 288–291
نویسندگان
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