کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4209276 1280476 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pulmonary outcome differences in U.S. and French cystic fibrosis cohorts diagnosed through newborn screening
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Pulmonary outcome differences in U.S. and French cystic fibrosis cohorts diagnosed through newborn screening
چکیده انگلیسی

BackgroundA comparison of the longitudinal progression of lung disease in cystic fibrosis patients identified through newborn screening (NBS) in cohorts located in two different countries has never been performed and was the primary objective of this study.MethodsThe study included 56 patients in Brittany diagnosed through NBS between 1989 and 1994 and 69 similar patients in Wisconsin between 1985 and 1994. The onset and progression of lung disease was radiographically quantified using the Wisconsin Chest X-ray (WCXR) scoring system. A single pediatric pulmonologist blinded to all identifiers scored the films.ResultsGeneralized estimating equation analyses adjusted for age, genotype, sex, pancreatic insufficiency, and meconium ileus showed worse WCXR scores in Brittany patients compared to Wisconsin patients (average score difference = 4.48; p < 0.001). Percent predicted FEV1 was also worse among Brittany patients (p < 0.001).ConclusionsThe finding of milder radiographically-quantified lung disease using the WCXR scoring system, as well as better FEV1 values, may be explained by variations in nutrition, environmental exposures, or healthcare delivery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 9, Issue 1, January 2010, Pages 44–50
نویسندگان
, , , , , , , , ,