کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4210740 1280608 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blood biomarkers and measures of pulmonary function–A study from the Swedish twin registry
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Blood biomarkers and measures of pulmonary function–A study from the Swedish twin registry
چکیده انگلیسی

SummaryObjectiveThere is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function.MethodsFEV1, FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (DLCO) were assessed in 357 subjects from the Swedish Twin Registry. The lung function measures were studied in relation to plasma levels of desmosines, C-reactive protein (CRP), plasminogen inhibitor activator (PAI-1) concentration and activity, tissue inhibitor of metalloproteinase (TIMP-1), clara cell protein 16 (CC16), surfactant protein D (SPD), matrix metalloproteinase 9 (MMP-9), hepatocyte growth factor (HGF) and interleukin (IL)-8.ResultsAfter adjustments for age, sex, height, BMI and smoking, FEV1 was significantly associated with PAI-1 activity and desmosines. RV/TLC was significantly associated with CC16, PAI-1 concentration and PAI-1 activity, and DLCO was significantly associated with desmosines, TIMP-1 and CRP. When the multivariate analysis was restricted to subjects with COPD (i.e., FEV1/FVC < 0.70), CRP and desmosines were inversely associated with lung function.ConclusionSeveral biomarkers were associated with lung function in this cross-sectional study. Especially CRP and desmosines could be useful markers to assess disease severity in subjects with COPD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 106, Issue 9, September 2012, Pages 1250–1257
نویسندگان
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