کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4212507 1280699 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Apoptosis of peripheral blood neutrophils in COPD exacerbation does not correlate with serum cytokines
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Apoptosis of peripheral blood neutrophils in COPD exacerbation does not correlate with serum cytokines
چکیده انگلیسی

SummaryThe study investigated the relationship between apoptosis of peripheral blood neutrophils during exacerbation of chronic obstructive pulmonary disease (COPD) and the inflammatory response that characterises this condition. Twenty-six hospitalised patients with COPD exacerbation and 13 controls were included. Three sequential blood and sputum samples were obtained from patients at admission, after 3 days and at discharge. Blood apoptotic neutrophils were measured by flow-cytometry and light microscopy. Serum and sputum levels of IL-6, IL-8 and TNF-α were determined by an immunoassay technique. We found a significantly reduced percentage of apoptotic neutrophils at the onset of COPD exacerbation which increased over time (1.1±0.4% at admission vs.   2.4±0.4% at discharge, P<0.0001P<0.0001). Patients presented no changes in serum cytokines neither during exacerbation nor in comparison to controls. In contrast, sputum levels of cytokines were significantly increased compared to serum levels. There was no significant correlation between the apoptotic neutrophils and the cytokine concentrations in serum or sputum. None of the clinical parameters, such as smoking, microbial infection, corticosteroids or hypoxemia showed a correlation with neutrophil apoptosis. No relationship could be found between the reduced percentage of apoptotic neutrophils in blood and serum concentration of IL-6, IL-8 and TNF-α or other clinical parameters in patients with COPD exacerbation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 100, Issue 4, April 2006, Pages 639–647
نویسندگان
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