Effect of Aging and Cardiovascular Risk Factors on Receptor Tie1 Expression in Human Erectile Tissue

Employing different methodological approaches, we show for the first time that Tie1 is expressed in human CC endothelium, and its level of expression diminishes in aged individuals, particularly those with CVDRF. This finding reinforces the view that delivery of Ang1 to the CC of erectile dysfunction affected CVDRF patients is able to activate a beneficial Tie2 response. Fonseca J, Tomada N, Magalhães A, Rodrigues AR, Gouveia AM, and Neves D. Effect of aging and cardiovascular risk factors on receptor Tie1 expression in human erectile tissue. J Sex Med 2015;12:876-886.