کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4269630 1610846 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in Vaginal Physiology of Menopausal Women with Type 2 Diabetes
ترجمه فارسی عنوان
تغییرات فیزیولوژی واژینال زنان یائسه مبتلا به دیابت نوع 2
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی اورولوژی
چکیده انگلیسی

IntroductionMetabolic disorders, such as type 2 diabetes, have been associated with an increased risk of development of female sexual dysfunction (FSD). In experimental studies, vascular, neuronal, and hormonal responsiveness alteration at vaginal level were proposed as contributors to the onset of FSD in women with diabetes; however, conclusive data on humans are still lacking.AimsThe study aimed to assess changes in vascularization, sex steroid receptors, nitric oxide synthase, and aquaporin-2 (AQP2) expression occurring at vaginal level in women with diabetes.MethodsVaginal biopsies were obtained from 21 postmenopausal women, 10 of whom were diagnosed as having type 2 diabetes mellitus. CD31, estrogen receptor-α (ERα) and androgen receptor (AR) expression and localization were analyzed by immunostaining. Expression of endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase isoforms and AQP2 were also assessed in vaginal samples.Main Outcomes MeasuresChanges in vaginal vascularization, sex steroids receptor, eNOS, nNOS and AQP2 expression.ResultsVaginal samples from women with diabetes showed an increased microvessel density in the lamina propria, which were morphologically disrupted suggesting an angiogenic compensatory mechanism. While no differences were seen in ERα, AR expression was significantly reduced in the vaginal epithelium and lamina propria of women with diabetes. Similarly, the gene and protein expressions of both nNOS and eNOS were significantly reduced in patients with diabetes, while AQP2 mRNAs level did not significantly differ between the two groups.ConclusionDiabetes greatly impacts vaginal physiology, being associated with alterations of the vaginal lamina propria vascular network, nitrergic signaling, and AR expression. These alterations may contribute to the increased risk of FSD development in women with diabetes. Baldassarre M, Alvisi S, Berra M, Martelli V, Farina A, Righi A, and Meriggiola MC. Changes in vaginal physiology of menopausal women with type 2 diabetes. J Sex Med 2015;12:1346–1355.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Sexual Medicine - Volume 12, Issue 6, June 2015, Pages 1346–1355
نویسندگان
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