Superoxide Anion Production by NADPH Oxidase Plays a Major Role in Erectile Dysfunction in Middle‐Aged Rats: Prevention by Antioxidant Therapy

ED in middle‐aged rats is associated with decreased NO bioavailability in erectile tissue due to upregulation of NADPH oxidase subunit gp91phox and downregulation of nNOS/p‐eNOS. Antioxidant therapies may be a good pharmacological approach to prevent ED at its early stages.