Separate or Combined Treatments with Daily Sildenafil, Molsidomine, or Muscle‐Derived Stem Cells Prevent Erectile Dysfunction in a Rat Model of Cavernosal Nerve Damage

Conclusions.  Lowering the dose of a continuous long‐term sildenafil administration still maintained the prevention of CVOD in the BCNR rat previously observed, but it was less effective on the underlying histopathology. As in the aging rat model, MDSC also counteracted CVOD, but supplementation with very low‐dose sildenafil did not improve the outcome. Kovanecz I, Rivera S, Nolazco G, Vernet D, Segura D, Gharib S, Rajfer J, and Gonzalez‐Cadavid NF. Separate or combined treatments with daily sildenafil, molsidomine, or muscle‐derived stem cells, prevent erectile dysfunction in a rat model of cavernosal nerve damage. J Sex Med 2012;9:2814-2826.