Change of Erectile Function and Responsiveness to Phosphodiesterase Type 5 Inhibitors at Different Stages of Streptozotocin-Induced Diabetes in Rats

Impairment of erectile function was followed by decreased responsiveness to PDE5I during the course of diabetes. The RhoA/ROCK pathway played an important role in diabetes-associated ED. Cho SY, Park K, Paick J-S, and Kim SW. Change of erectile function and responsiveness to PDE5 (Type 5 phosphodiesterase) inhibitors at different stages of streptozotocin-induced diabetes in rats.