Role of Chloride Channels in the Regulation of Corpus Cavernosum Tone: A Potential Therapeutic Target for Erectile Dysfunction

These results underline the importance of Cl− currents as a mechanism in the maintenance of cavernosal tone produced by adrenergic and various endogenous constrictors. Thus, the modulation of Cl− current, as an attractive and effective approach to regulate penile erection, and specific ClC blockers, as potential erectogenic agents, merits further research. Lau LC, and Adaikan PG. Role of chloride channels in the regulation of corpus cavernosum tone: A potential therapeutic target for erectile dysfunction.