NADPH Oxidase Activation: A Mechanism of Hypertension-Associated Erectile Dysfunction

These data suggest that activation of NADPH oxidase is a molecular mechanism for hypertension-associated ED. Apocynin treatment exerted protective effects on erectile function through inhibition of NADPH oxidase activity, thereby reducing oxidative stress in Ang II-infused hypertensive rats. This is the first study to identify the importance of NADPH oxidase in the regulation of erectile function in vivo. Jin L, Lagoda G, Leite R, Webb RC, and Burnett AL. NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction