How Does Chronic Sildenafil Prevent Vascular Oxidative Stress in Insulin-Resistant Rats?

The present study showed that chronic sildenafil produced sustained vascular antioxidant effects in insulin-resistant rats by increasing NO release and regulating vascular superoxide release, supporting therefore further investigations using chronic sildenafil administration in preventing cardiovascular alterations associated with oxidative stress. Oudot A, Behr-Roussel D, Le Coz O, Poirier S, Bernabe J, Alexandre L, and Giuliano F. How does chronic sildenafil prevent vascular oxidative stress in insulin-resistant rats? J Sex Med 2010;7:79-88.