FK506 and Erectile Function Preservation in the Cavernous Nerve Injury Model: Optimal Dosing and Timing

These results suggest that short-term treatment with doses of FK506 higher than previously utilized preserves erectile function in the rat CN-injury model. Pretreatment appears to offer no advantage. However, FK506 administration just prior to CN injury and for a short-time post-injury achieves the best functional and structural preservation outcomes. Mulhall JP, Müller A, Donohue JF, Golijanin D, Tal R, Akin-Olugbade Y, Kobylarz K, Cohen-Gould L, Bennett NE, and Scardino P. FK506 and erectile function preservation in the cavernous nerve injury model: Optimal dosing and timing.