کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4279276 1611519 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Streamlining of intra-operative parathyroid hormone measurements for cure during parathyroidectomy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Streamlining of intra-operative parathyroid hormone measurements for cure during parathyroidectomy
چکیده انگلیسی

BackgroundThe timing of intraoperative parathyroid hormone measurements during parathyroidectomy for the treatment of primary hyperparathyroidism is quite variable. Although a 50% decrease after excision is considered predictive of cure, it is not known which combination of measurements is most useful.MethodsTwo hundred thirteen patients underwent resection of solitary parathyroid adenomas. Sex, age, intraoperative parathyroid hormone level at baseline, before adenoma removal (T0), and 5 minutes (T5) and 10 minutes (T10) after adenoma removal; and 50% decrease were tested for associations with cure.ResultsA 50% decrease in intraoperative parathyroid hormone level was 95% sensitive for cure (95% confidence interval, 89% to 98%) but did not predict cure for individual patients. A decrease into the normal range was not correlated with cure (P > .50). However, a 50% decrease from T0 to T10 was 97% predictive of cure (odds ratio, 6.5; P = .08).ConclusionsThe decrease in parathyroid hormone level from T0 to T10 during parathyroidectomy was most predictive of cure of primary hyperparathyroidism. A decrease into the normal range did not improve the performance characteristics of this test.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 205, Issue 5, May 2013, Pages 597–601
نویسندگان
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