Topical gentamicin does not provide any additional anastomotic strength when combined with fibrin glue

BackgroundWe evaluated the effect of a combination of fibrin sealant and topical gentamicin on a colonic anastomosis in a rat model.MethodsPartial anastomosis in the transverse colon was performed in 70 male Sprague–Dawley rats aged 6 to 10 weeks using 5 interrupted sutures. The rats were divided into 4 groups (control, gentamicin, fibrin glue, and combination). On postoperative days 3 and 5, the rats in each group were killed, anastomotic bursting pressures scores and bowel loop adhesions were determined, and histologic examination was performed.ResultsNo significant difference was noted in the bursting pressures, adhesions, inflammatory infiltrates, fibroblasts, or neoangiogenesis between the fibrin-glue only and the combination groups for both the day 3 and day 5 subgroups.ConclusionsThe combination of topical gentamicin and fibrin glue had little effect because the combination did not provide additional anastomotic strength or decrease the number of adhesions when compared with fibrin glue alone.