کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4281483 | 1611586 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Recent advances in the diagnosis and treatment of pheochromocytoma in children Recent advances in the diagnosis and treatment of pheochromocytoma in children](/preview/png/4281483.png)
BackgroundThe purpose of this study was to analyze the effects of changes in the diagnosis and treatment of pheochromocytoma in a pediatric population.MethodsWe reviewed the medical records of all children who had resection of pheochromocytoma or paraganglioma at a major children’s hospital since 1968.ResultsFifteen children underwent surgery at 11.9 ± 4.2 years of age. Presenting symptoms included headache, hypertension, and sweating. Three children had a mutation of the succinate dehydrogenase enzyme, and 1 child had nonsyndromic, familial pheochromocytoma. The most sensitive diagnostic modalities included 24-hour urinary and plasma norepinephrine and 24-hour urinary total metanephrines, magnetic resonance imaging, and 123I–meta-iodobenzylguanidine scintigraphy. Laparoscopic cortical-sparing adrenalectomy was performed in 3 patients with von Hippel-Lindau disease. Compared with those with open procedures (n = 7), patients who had laparoscopic resection (n = 5) had a statistically shorter hospital length of stay, and time to eating ambulation.ConclusionsThe addition of 123I–meta-iodobenzylguanidine scanning, genetic testing, and laparoscopic surgery has changed the diagnosis and treatment of pheochromocytoma in children. Laparoscopic cortical-sparing adrenalectomy can be accomplished safely and is the preferred treatment for children at risk for multifocal disease.
Journal: The American Journal of Surgery - Volume 194, Issue 6, December 2007, Pages 792–797