کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4282590 1611753 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of postoperative changes in antihypertensive drug consumption in patients with primary aldosteronism using the defined daily dose
ترجمه فارسی عنوان
ارزیابی تغییرات پس از عمل در مصرف داروهای ضد فشار خون در بیماران مبتلا به آلدوسترونیزیم اولیه با استفاده از دوز روزانه تعریف شده
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

SummaryBackgroundThe number of antihypertensive drug classes cannot accurately reflect the total consumption of antihypertensive drugs used to control blood pressure. The defined daily dose has been adopted to permit consumption analysis of many prescribed drugs. The aim of the present study was to assess postoperative changes in antihypertensive drug consumption in patients with primary aldosteronism using the defined daily dose as the unit of measurement.MethodsThis retrospective study included 110 Japanese patients who underwent unilateral laparoscopic adrenalectomy between 1995 and 2012. Antihypertensive drug doses were calculated according to the standard of the defined daily dose recommended by the World Health Organization to compare drug use. After assessing postoperative changes in antihypertensive drug consumption, univariate and multivariate analyses were performed to identify clinical predictors for a 75% or greater decrease in the defined daily dose.ResultsConsumption of antihypertensive drugs decreased postoperatively in 95.4% of patients. The median decrease in the defined daily dose was 76.8%. A postoperative decrease of 75% or greater in the defined daily dose was confirmed in 52.7% of patients. Multivariate analysis identified no medical history of cardiovascular disease, low body mass index, and short duration of hypertension as independent predictors of a postoperative decrease of 75% or greater in the defined daily dose.ConclusionThe defined daily dose is a useful tool for assessing total changes in the consumption of antihypertensive drugs in patients with primary aldosteronism. Using the defined daily dose, clinicians could explain in detail to patients with primary aldosteronism the predicted postoperative change in antihypertensive drug consumption.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Surgery - Volume 37, Issue 4, October 2014, Pages 190–194
نویسندگان
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