کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4299637 1288397 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved angiogenesis and healing in crush syndrome by fibroblast growth factor-2–containing low-molecular-weight heparin (Fragmin)/protamine nanoparticles
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Improved angiogenesis and healing in crush syndrome by fibroblast growth factor-2–containing low-molecular-weight heparin (Fragmin)/protamine nanoparticles
چکیده انگلیسی

BackgroundWe produced fibroblast growth factor (FGF)-2–containing low-molecular-weight heparin (Fragmin)/protamine nanoparticles (FGF-2 + F/P NPs). The purpose of this study was to evaluate the effectiveness of the local administration of FGF-2 + F/P NPs on repairing crush syndrome (CS)-injured lesions after compression release using a nonlethal and reproducible CS injury rat model.Materials and methodsThe hind limbs of the anesthetized rats were compressed for 6 h using 3.6 kg blocks, as previously described. The effects of administering FGF-2 + F/P NPs (group A), F/P NPs alone (group B), FGF-2 alone (group C), and saline (control; group D) were examined. Motor function, surface blood flow in the hind limbs, and the wet/dry weight ratio in the tibialis anterior muscle were examined for 1–28 d after the compression release. Histologic analyses were also performed.ResultsAt the middle and late stages (3–28 d after the compression release), group A had higher scores in the motor function, improved blood flow, increased number of blood vessels, and faster recovered muscle tissue, compared with the other groups. There was no significant difference in enhanced edema in the tibialis anterior muscle among all groups.ConclusionsThe local administration of FGF-2 + F/P NPs to a CS-injured lesion was effective in repairing damaged muscle tissue after compression release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 196, Issue 2, 15 June 2015, Pages 247–257
نویسندگان
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