کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4299653 | 1288397 | 2015 | 5 صفحه PDF | دانلود رایگان |
BackgroundCoagulopathy after injury contributes to hemorrhage and death. Treatment with specific coagulation factors could decrease hemorrhage and mortality. Our aim was to compare fibrinogen and prothrombin complex concentrate (PCC) in a rabbit model of hemorrhagic shock.Materials and methodsNew Zealand white rabbits were anesthetized. Blood was withdrawn to a mean arterial pressure (MAP) of 30–40 mm Hg for 30 min. Animals were resuscitated with lactated Ringer to a MAP of 50–60 mm Hg and randomized to receive 100 mg/kg of fibrinogen, PCC 25 IU/kg, or lactated Ringer. A liver injury was created. A MAP of 50–60 mm Hg was maintained for 60 min. The primary outcome was blood loss, and secondary outcomes were fluid administered and coagulopathy as measured by plasma-based tests.ResultsThere were eight animals in each group. Median blood loss was significantly higher in the fibrinogen group, at 122 mL (95% confidence interval [CI], 75–194), when compared with that in the control group, 35 mL (95% CI, 23–46; P value = 0.001), and the PCC group, 26 mL (95% CI, 4–54; P value = 0.002). Resuscitation fluid requirement was highest in the fibrinogen group, at 374 mL (95% CI, 274–519), and lowest in the PCC group, at 238 mL (95% CI, 212–309) (P = 0.01). Plasma-based coagulation tests were not different among groups.ConclusionsIn a rabbit model, PCC did not have a significant effect on blood loss. Fibrinogen increased blood loss and fluid requirements.
Journal: Journal of Surgical Research - Volume 196, Issue 2, 15 June 2015, Pages 368–372