کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4301977 1288447 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Function of Poly (lactic-co-glycolic acid) Nanofiber in Reduction of Adhesion Bands
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Function of Poly (lactic-co-glycolic acid) Nanofiber in Reduction of Adhesion Bands
چکیده انگلیسی

BackgroundIn this study, we investigated the anti-adhesive and anti-inflammatory effects of electrospun nanofibrous membranes made of polycaprolactone (PCL), poly-L-lactide (PLLA), poly (lactic-co-glycolic acid) (PLGA), and polyethersulfune (PES) in comparison with the oxidized-regenerated cellulose (Interceed).Materials and MethodsUsing an adhesion induction model in mice, the membranes were sutured between the abdominal wall and peritoneum after surgical operation to reveal the best membrane for prevention of postoperative adhesion bands using two scoring adhesion systems.ResultsCompared with other membranes, PLGA, PCL, and Interceed membranes showed a greater ability to reduce adhesions. The lowest level of inflammation in adhesive tissues as well as cell attachment in vitro was detected for PLGA nanofibrous membranes.ConclusionsThese results suggested that in considering the FDA approved polymers, nanofibrous membranes prepared from PLGA exhibited the highest efficacy for the prevention of postoperative adhesion bands and hold promising potential for application as a new anti-adhesive agent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 172, Issue 1, January 2012, Pages e1–e9
نویسندگان
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