کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4303584 1288482 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MUC1 Knockdown With RNA Interference Inhibits Pancreatic Cancer Growth
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
MUC1 Knockdown With RNA Interference Inhibits Pancreatic Cancer Growth
چکیده انگلیسی

MUC1, a tumor associated glycoprotein over-expressed in 95% of pancreatic cancers, has been shown to be associated with a worse prognosis. The objective of this study was to determine the impact of loss of MUC1 expression on pancreatic tumor growth. PANC1 human pancreatic carcinoma cells with stable “knockdown” MUC1 expression were created using a MUC1 specific short interfering RNA (siRNA). PANC1 cells with “knockdown” MUC1 expression had decreased in vitro proliferation compared with PANC1 wild type and control cells. PANC1-MUC1siRNA cells grew significantly slower in severe combined immunodeficient (SCID) mice compared with wild type and negative controls. Our data suggested that decreasing MUC1 tumor expression by RNA interference may be a novel molecular approach for the treatment of pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 157, Issue 1, November 2009, Pages e39–e46
نویسندگان
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