کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4312958 1289978 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of novelty and methamphetamine on conditioned and sensory reinforcement
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Effects of novelty and methamphetamine on conditioned and sensory reinforcement
چکیده انگلیسی

BackgroundLight onset can be both a sensory reinforcer (SR) with intrinsic reinforcing properties, and a conditioned reinforcer (CR) which predicts a biologically important reinforcer. Stimulant drugs, such as methamphetamine (METH), may increase the reinforcing effectiveness of CRs by enhancing the predictive properties of the CR. In contrast, METH-induced increases in the reinforcing effectiveness of SRs, are mediated by the immediate sensory consequences of the light.MethodsThe effects of novelty (on SRs) and METH (on both CRs and SRs) were tested. Experiment 1: rats were pre-exposed to 5 s light and water pairings presented according to a variable-time (VT) 2 min schedule or unpaired water and light presented according to independent, concurrent VT 2 min schedules. Experiment 2: rats were pre-exposed to 5 s light presented according to a VT 2 min schedule, or no stimuli. In both experiments, the pre-exposure phase was followed by a test phase in which 5 s light onset was made response-contingent on a variable-interval (VI) 2 min schedule and the effects of METH (0.5 mg/kg) were determined.ResultsNovel light onset was a more effective reinforcer than familiar light onset. METH increased the absolute rate of responding without increasing the relative frequency of responding for both CRs and SRs.ConclusionNovelty plays a role in determining the reinforcing effectiveness of SRs. The results are consistent with the interpretation that METH-induced increases in reinforcer effectiveness of CRs and SRs may be mediated by immediate sensory consequences, rather than prediction.


► Novel light onset is a more effective reinforcer than familiar light onset.
► Meth increases responding but not preference for conditioned or sensory reinforcers.
► Meth may enhance immediate sensory rather than predictive properties of stimuli.
► The effects of meth on sensory reinforcement may be mediated by DA.
► Reinforcing effectiveness of abused drugs may be mediated by sensory reinforcers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 234, Issue 2, 1 October 2012, Pages 312–322
نویسندگان
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