کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4313333 | 1289993 | 2011 | 6 صفحه PDF | دانلود رایگان |

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.
► The MIA model produces schizophrenia-like memory impairment in rats.
► MIA produces a reduced reinstatement of rearing after a change in context.
► MIA animals show a less persistent reinstatement of rearing after contextual change.
► MIA is associated with schizophrenia-like contextual processing impairments.
► These impairments may be associated with damage to the hippocampus or its afferents.
Journal: Behavioural Brain Research - Volume 225, Issue 1, 20 November 2011, Pages 382–387