کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313333 1289993 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia
چکیده انگلیسی

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.


► The MIA model produces schizophrenia-like memory impairment in rats.
► MIA produces a reduced reinstatement of rearing after a change in context.
► MIA animals show a less persistent reinstatement of rearing after contextual change.
► MIA is associated with schizophrenia-like contextual processing impairments.
► These impairments may be associated with damage to the hippocampus or its afferents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 225, Issue 1, 20 November 2011, Pages 382–387
نویسندگان
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