Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response

▶ Neuropeptide S receptor-deficient C57BL/6 mice do not express neuropeptide S-induced hyperactivity but hyperactivity induced by cocaine. ▶ Neuropeptide S receptor deficiency impair spontaneous but not reactive locomotor activity. ▶ Neuropeptide S receptor deficiency has no effects in animal models of innate and learned fear. ▶ Neuropeptide S receptor deficiency reduces the acoustics startle magnitude but has no effects on prepulse inhibition.