The modified Geller-Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5-HT1A receptor activation

The modified Geller-Seifter task generally exhibits good predictive validity for anxiolytic-like compounds. Neither GABAB receptor positive allosteric modulation nor blockade exhibited anxiolytic-like properties in the modified Geller-Seifter task. The 5-HT1A partial agonist buspirone was similarly ineffective.